Preoperative PSMA PET/CT As Triage for Extended Pelvic Lymph Node Dissection (ePLND) in Patients Scheduled for Robot-Assisted Laparoscopic Radical Prostatectomy (RALP)
Extended pelvic lymph node dissection (ePLND) is considered the gold standard for nodal staging in men with prostate cancer (PCa). The aim of this project is to determine if preoperative prostate specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomograpy (CT) can safely replace ePLND as a staging method in PCa patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP).
• Biopsy proven diagnosed adenocarcinoma of the prostate
• Indication for ePLND combined with RALP:
• High-risk group (EAU) and including MRI findings indicating extra prostatic extension (Likert scale ≥4)
• -ISUP GG 3 with ≥1 of the following unfavourable risk factors
‣ cT2b-c,
⁃ ≥50% percentage of positive biopsy cores,
⁃ PSA 10-20
• cN1 selected to surgery
• Written informed consent
• No known allergies for PSMA tracer
• 18 years and older